Inducing Fat to Feed a Natural Killer of Malignancy
نویسندگان
چکیده
منابع مشابه
Pediatric Natural Killer Cell Malignancy
Natural killer (NK) cell malignancy is a heterogeneous disorder and rare, representing <1% of non-Hodgkin lymphomas for most of the world, except in Asia and Latin America. In Asia, especially, the incidence of NK-cell lymphomas is approximately 7%–10% of lymphomas [Au et al., 2005]. The pathogenesis of NK-cell malignancies has not yet been fully elucidated. In the 2008 World Health Organizatio...
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Harnessing the immune system has proven an effective therapy in treating malignancies. Since the discovery of natural killer (NK) cells, strategies aimed to manipulate and augment their effector function against cancer have been the subject of intense research. Recent progress in the immunobiology of NK cells has led to the development of promising therapeutic approaches. In this review, we wil...
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Natural killer T cells (NKT cells) are selected in the thymus by self-glycolipid antigens presented by CD1d molecules. It is currently thought that one specific component of the lysosomal processing pathway, which leads to the production of isoglobotrihexosylceramide (iGb3), is essential for normal NKT cell development. New evidence now shows that NKT cell development can be disrupted by a dive...
متن کاملTHE CYTOTOXICITY PATHWAY OF NATURAL KILLER CELLS IN CORD BLOOD COMPARED TO P ERIPHERAL BLOOD
The cytotoxic activity of natural killer cells is usually tested by radioactive assay CSI Cr release assay), which detects the release of cytoplasmic contents after plasma membrane disintegration of dying cells. In contrast to this indirect evaluation of cytotoxicity, the assessment of cell damage by flow cytometry aims to provide a more exact characterization of the death pathway via detec...
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The nonmetastatic neutrophilia-inducing murine mammary carcinoma CE 1460 has been shown previously to have profound effects on hemopoiesis and lymphopoiesis. In this report we examined the effects of progressive growth of CE1460 on natural killer (NK) cell activity both in the bone marrow, the site of primary NK cell production, and in a peripheral site, the spleen. (BALB/c x CE)Fi mice were in...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2019
ISSN: 1525-0016
DOI: 10.1016/j.ymthe.2019.04.005